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Assessing a hyperpolarized [1-13C]-labeled alanine derivative enhanced via parahydrogen for in vivo studies

MPS-Authors
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Fries,  Lisa M.
Research Group of NMR Signal Enhancement, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Moll,  Denis
Research Group of NMR Signal Enhancement, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Mei,  Ruhuai
Research Group of NMR Signal Enhancement, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Hune,  Theresa L. K.
Research Group of NMR Signal Enhancement, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Elsaßer,  Josef
Research Group of NMR Signal Enhancement, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Glöggler,  Stefan
Research Group of NMR Signal Enhancement, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Citation

Fries, L. M., Moll, D., Mei, R., Hune, T. L. K., Elsaßer, J., & Glöggler, S. (2025). Assessing a hyperpolarized [1-13C]-labeled alanine derivative enhanced via parahydrogen for in vivo studies. Journal of Magnetic Resonance Open, 22: 100183. doi:10.1016/j.jmro.2024.100183.


Cite as: https://hdl.handle.net/21.11116/0000-0010-6291-B
Abstract
Magnetic Resonance Imaging (MRI) is a valuable non-invasive technique widely used in clinical diagnostics; however, its sensitivity is limited, posing challenges in various medical conditions. Hyperpolarization techniques represent a promising approach to dramatically enhance signals in magnetic resonance imaging (MRI) and allow the use endogenous metabolites as contrast media. In this study, we synthesized N-acetyl-alanine ethyl ester as a novel imaging agent and assessed its in vivo imaging capabilities, potentially offering diagnostic and monitoring capabilities for cardiovascular diseases. It is derived from N-acetyl-alanine, an endogenous metabolic end product of protein degradation. The in vivo experiments resulted in high-resolution images of the circulatory system acquired within sub-seconds. Our findings not only highlight the potential preclinical utility of this new, generally available agent, but also advance the frontier of hyperpolarized contrast agents.