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Journal Article

Bridging the gap: How enhancers cooperate to regulate gene expression over large genomic distances

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Tsouraki,  Dimitra
Lise Meitner Group Genome Organization and Regulation, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Oudelaar,  A. Marieke       
Lise Meitner Group Genome Organization and Regulation, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Citation

Tsouraki, D., & Oudelaar, A. M. (2025). Bridging the gap: How enhancers cooperate to regulate gene expression over large genomic distances. Molecular Cell, 85(2), 199-201. doi:10.1016/j.molcel.2024.12.001.


Cite as: https://hdl.handle.net/21.11116/0000-0010-7AF0-6
Abstract
By building synthetic regulatory landscapes, Jensen et al.1 and Thomas et al.2 demonstrate in this issue of Molecular Cell that gene expression levels strongly depend on the genomic distance between enhancers and promoters and that enhancer cooperation can compensate for reduced enhancer activity over large genomic distances.