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Journal Article

Gut bacterial metabolism produces neuroactive steroids in pregnant women

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Huus,  KE       
Department Microbiome Science, Max Planck Institute for Biology Tübingen, Max Planck Society;

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Ley,  RE       
Department Microbiome Science, Max Planck Institute for Biology Tübingen, Max Planck Society;

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Citation

Huus, K., & Ley, R. (2024). Gut bacterial metabolism produces neuroactive steroids in pregnant women. Life Metabolism, 3(6): loae030. doi:10.1093/lifemeta/loae030.


Cite as: https://hdl.handle.net/21.11116/0000-0010-8661-9
Abstract
A multitude of bioactive compounds are produced by the gut microbiota, including metabolites with notable antimicrobial or immunomodulatory effects. Perhaps the most compelling of these compounds, however, are the ones with the potential to affect human mood and behavior. In an article published recently in Cell, McCurry et al. demonstrated that human gut bacteria are capable of producing neuroactive steroids, including a drug clinically approved by the United States Food and Drug Administration (FDA) for the treatment of postpartum depression.