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Incorporation of fluoroacetate into an aromatic polyketide and its influence on the mode of cyclization

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Spiteller,  D.
Department of Bioorganic Chemistry, MPI for Chemical Ecology, Max Planck Society;

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Citation

Hong, H., Spiteller, D., & Spencer, J. B. (2008). Incorporation of fluoroacetate into an aromatic polyketide and its influence on the mode of cyclization. Angewandte Chemie, International Edition, 47(32), 6028-6032. doi:10.1002/anie.200801100.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0012-A0D5-3
Abstract
Fluorine, changing course: Challenging the actinorhodin minimal polyketide synthase (act‐minimal PKS) with fluoroacetyl‐CoA as a starter unit yielded a fluorinated octaketide intermediate that led to the selective formation of fluoro‐SEK4b (see scheme); no fluoro‐SEK4 was formed(not shown).