English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Incorporation of fluoroacetate into an aromatic polyketide and its influence on the mode of cyclization

MPS-Authors
/persons/resource/persons4189

Spiteller,  D.
Department of Bioorganic Chemistry, MPI for Chemical Ecology, Max Planck Society;

External Resource
No external resources are shared
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
Citation

Hong, H., Spiteller, D., & Spencer, J. B. (2008). Incorporation of fluoroacetate into an aromatic polyketide and its influence on the mode of cyclization. Angewandte Chemie, International Edition, 47(32), 6028-6032. doi:10.1002/anie.200801100.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0012-A0D5-3
Abstract
Fluorine, changing course: Challenging the actinorhodin minimal polyketide synthase (act‐minimal PKS) with fluoroacetyl‐CoA as a starter unit yielded a fluorinated octaketide intermediate that led to the selective formation of fluoro‐SEK4b (see scheme); no fluoro‐SEK4 was formed(not shown).