The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: 
characterisation of an aminotransferase involved in the formation of 
2-deoxystreptamine

Huang, F. L.; Haydock, S. F.; Mironenko, T.; Spiteller, D.; Li, Y. Y.; Spencer, J. B.

doi:10.1039/B501199J

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The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: characterisation of an aminotransferase involved in the formation of 2-deoxystreptamine

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Spiteller, D.
Department of Bioorganic Chemistry, MPI for Chemical Ecology, Max Planck Society;

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Citation

Huang, F. L., Haydock, S. F., Mironenko, T., Spiteller, D., Li, Y. Y., & Spencer, J. B. (2005). The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: characterisation of an aminotransferase involved in the formation of 2-deoxystreptamine. Organic & Biomolecular Chemistry, 3(8), 1410-1418. doi:10.1039/B501199J.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-A0EA-6

Abstract

The biosynthetic gene cluster of the 2-deoxystreptamine (DOS)-containing aminoglycoside antibiotic neomycin has been cloned for the first time by screening of a cosmid library of Streptomyces fradiae NCIMB 8233. Sequence analysis has identified 21 putat