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A gene cluster from a marine Streptomyces encoding the biosynthesis of the aromatic spiroketal polyketide griseorhodin A

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Li,  A. Y.
Department of Bioorganic Chemistry, MPI for Chemical Ecology, Max Planck Society;

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Piel,  J.
Department of Bioorganic Chemistry, MPI for Chemical Ecology, Max Planck Society;

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Citation

Li, A. Y., & Piel, J. (2002). A gene cluster from a marine Streptomyces encoding the biosynthesis of the aromatic spiroketal polyketide griseorhodin A. Chemistry & Biology, 9(9), 1017-1026. doi:10.1016/S1074-5521(02)00223-5.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0012-A198-7
Abstract
The telomerase inhibitor griseorhodin A is probably the most heavily oxidized bacterial polyketide known and features a unique epoxyspiroketal moiety crucial for its activity. To gain insight into which tailoring enzymes generate this pharmacophore, we