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A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles

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Piel,  J.
Department of Bioorganic Chemistry, MPI for Chemical Ecology, Max Planck Society;

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Citation

Piel, J. (2002). A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles. Proceedings of the National Academy of Sciences of the United States of America, 99(22), 14002-14007. doi:10.1073/pnas.222481399.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0012-A269-9
Abstract
Many drug candidates from marine and terrestrial invertebrates are suspected metabolites of uncultured bacterial symbionts. The antitumor polyketides of the pederin family, isolated from beetles and sponges, are an example. Drug development from such so