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Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase

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Piel,  J.
Department of Bioorganic Chemistry, MPI for Chemical Ecology, Max Planck Society;

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Hertweck,  C.
Department of Bioorganic Chemistry, MPI for Chemical Ecology, Max Planck Society;

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Citation

Piel, J., Hertweck, C., Shipley, P. R., Hunt, D. M., Newman, M. S., & Moore, B. S. (2000). Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase. Chemistry & Biology, 7(12), 943-955. doi:10.1016/s1074-5521(00)00044-2.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0012-A27F-A
Abstract
Background: Polycyclic aromatic polyketides, such as the tetracyclines and anthracyclines, are synthesized by bacterial aromatic polyketide synthases (PKSs). Such PKSs contain a single set of iteratively used individual proteins for the construction of