Regulation of phenylalanine biosynthesis. Studies on the mechanism of 
phenylalanine binding and feedback inhibition in the Escherichia coli P-protein

Pohnert, G.; Zhang, S.; Husain, A.; Wilson, D. B.; Ganem, B.

doi:10.1021/bi991134w

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Regulation of phenylalanine biosynthesis. Studies on the mechanism of phenylalanine binding and feedback inhibition in the Escherichia coli P-protein

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Pohnert, G.
Department of Bioorganic Chemistry, MPI for Chemical Ecology, Max Planck Society;

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Citation

Pohnert, G., Zhang, S., Husain, A., Wilson, D. B., & Ganem, B. (1999). Regulation of phenylalanine biosynthesis. Studies on the mechanism of phenylalanine binding and feedback inhibition in the Escherichia coli P-protein. Biochemistry, 38(38), 12212-12217. doi:10.1021/bi991134w.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-A2E5-F

Abstract

Isothermal titration calorimetry (ITC) and site-directed mutagenesis were used to study the interaction of Phe with (a) the Escherichia coli P-protein, a bifunctional chorismate mutase/prephenate dehydratase that is feedback inhibited by Phe, (b) PDT32,