Molecular basis of Celmer's rules: Stereochemistry of catalysis by isolated 
ketoreductase domains from modular polyketide synthases

Siskos, A. P.; Baerga-Ortiz, A.; Bali, S.; Stein, V.; Mamdani, H.; Spiteller, D.; Popovic, B.; Spencer, J. B.; Staunton, J.; Weissman, K. J.; Leadlay, P. F.

doi:10.1016/j.chembiol.2005.08.017

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Molecular basis of Celmer's rules: Stereochemistry of catalysis by isolated ketoreductase domains from modular polyketide synthases

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Spiteller, D.
Department of Bioorganic Chemistry, MPI for Chemical Ecology, Max Planck Society;

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Citation

Siskos, A. P., Baerga-Ortiz, A., Bali, S., Stein, V., Mamdani, H., Spiteller, D., et al. (2005). Molecular basis of Celmer's rules: Stereochemistry of catalysis by isolated ketoreductase domains from modular polyketide synthases. Chemistry & Biology, 12(10), 1145-1153. doi:10.1016/j.chembiol.2005.08.017.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-A36E-8

Abstract

A system is reported for the recombinant expression of individual ketoreductase (KR) domains from modular polyketide synthases (PKSs) and scrutiny of their intrinsic specificity and stereospecificity toward surrogate diketide substrates. The eryKR(1) an