English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Oxidation of linoleic acid in low-density lipoprotein: An important event in atherogenesis

MPS-Authors
/persons/resource/persons4189

Spiteller,  D.
Department of Bioorganic Chemistry, MPI for Chemical Ecology, Max Planck Society;

External Resource
No external resources are shared
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Spiteller, D., & Spiteller, G. (2000). Oxidation of linoleic acid in low-density lipoprotein: An important event in atherogenesis. Angewandte Chemie International Edition, 39(3), 585-589. doi:10.1002/(SICI)1521-3773(20000204)39:3<585:AID-ANIE585>3.0.CO;2-G.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0012-A398-6
Abstract
Contrary to earlier views the main oxidation products of low-density lipoprotein (LDL) are derived from linoleic acid and not arachidonic acid, as determined by GC/MS investigations of the in vitro oxidation of LDL samples. A similar product spectrum, in which epoxyhydroxyoctadecenoic acids such as 1 and 2 have been identified for the first time, is obtained from minimally oxidized (that is, aged) LDL. Since this is still recognized by the LDL receptor, it is concluded that toxic oxidation products are introduced in endothelial cells in vivo and cause damage there