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The role of ionic backbones in RNA structure: An unusually stable non-Watson-Crick duplex of a nonionic analog in an apolar medium

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Steinbeck,  C.
Department of Bioorganic Chemistry, MPI for Chemical Ecology, Max Planck Society;

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Citation

Steinbeck, C., & Richert, C. (1998). The role of ionic backbones in RNA structure: An unusually stable non-Watson-Crick duplex of a nonionic analog in an apolar medium. Journal of the American Chemical Society, 120(45), 11576-11580. doi:10.1021/ja9817951.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-A3CD-0
Abstract
The solution structure of a dimethylenesulfone-linked analogue of the RNA dimer UpC was determined using two-dimensional NMR and restrained molecular dynamics. In CDCl3, the RNA analogue forms a parallel duplex with a single U:U base pair and roughly an