Naturally occurring labdane diterpene and benzofuran from Globba pendula

Maulidiani,; Shaari, Khozirah; Paetz, C.; Stanslas, Johnson; Abas, Faridah; Lajis, Nordin Haji

doi:10.1177/1934578X0900400803

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Naturally occurring labdane diterpene and benzofuran from Globba pendula

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Paetz, C.
Research Group Biosynthesis / NMR, MPI for Chemical Ecology, Max Planck Society;

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Citation

Maulidiani, Shaari, K., Paetz, C., Stanslas, J., Abas, F., & Lajis, N. H. (2009). Naturally occurring labdane diterpene and benzofuran from Globba pendula. Natural Product Communications, 4(8), 1031-1036. doi:10.1177/1934578X0900400803.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-B518-A

Abstract

Phytochemical investigation on Globba pendula resulted in the isolation of a new naturally occurring 16-oxo-(8)17-12-labdadien-15,11-olide 1 and benzofuran-2-carboxaldehyde 2. Other known compounds including isoandrographolide, indirubin, vanillin, vanillic acid, 2(3H)-benzoxazolone, as well as beta-sitosteryl-beta-D-glucopyranoside, beta-sitosterol, and 7alpha-hydroxysitosterol were also isolated. The structures were established based on spectroscopic data and comparison with the literature. Furthermore, the compound isoandrographolide has demonstrated strong cytotoxic properties towards a panel of cancer cell lines (MCF-7, PC-3, and H-460) with the IC50 values of 7.9, 8.7, and 9.0 microM, respectively.