Entacapone and Tolcapone, two catechol-O-methyltransferase inhibitors (ICOMT), 
block fibril formation of {alpha}-synuclein and {beta}-amyloid and protect 
against amyloid-induced toxicity.

Di Giovanni, S.; Eleuteri, S.; Paleologou, K. E.; Yin, G.; Zweckstetter, M.; Carrupt, P. A.; Lashuel, H. A.

doi:10.1074/jbc.M109.080390

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Entacapone and Tolcapone, two catechol-O-methyltransferase inhibitors (ICOMT), block fibril formation of {alpha}-synuclein and {beta}-amyloid and protect against amyloid-induced toxicity.

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Yin, G.
Department of NMR Based Structural Biology, MPI for biophysical chemistry, Max Planck Society;

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Zweckstetter, M.
Research Group of Protein Structure Determination using NMR, MPI for biophysical chemistry, Max Planck Society;

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Di Giovanni, S., Eleuteri, S., Paleologou, K. E., Yin, G., Zweckstetter, M., Carrupt, P. A., et al. (2010). Entacapone and Tolcapone, two catechol-O-methyltransferase inhibitors (ICOMT), block fibril formation of {alpha}-synuclein and {beta}-amyloid and protect against amyloid-induced toxicity. Journal of Biological Chemistry, 285(20), 14941-14954. doi:10.1074/jbc.M109.080390.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-D59C-2

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