Long-range signalling in activation of the translational GTPase EF-Tu.

Rodnina, M. V.

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Long-range signalling in activation of the translational GTPase EF-Tu.

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Rodnina, M. V.
Department of Physical Biochemistry, MPI for biophysical chemistry, Max Planck Society;

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Rodnina, M. V. (2009). Long-range signalling in activation of the translational GTPase EF-Tu. EMBO Journal, 28(6), 619-620. Retrieved from http://www.nature.com/emboj/journal/v28/n6/pdf/emboj200950a.pdf.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-D8A8-0

Abstract

Elongation factor Tu (EF-Tu) is a GTPase that delivers aminoacyl-tRNA (aa-tRNA) to the ribosome during protein synthesis. The factor is activated in response to the correct recognition of the mRNA codon by the anticodon of the aa-tRNA. The mechanism of signalling between the decoding centre of the ribosome and the site of GTP hydrolysis in EF-Tu where GTP hydrolysis takes place is not known. New high-resolution cryo-electron microscopic (cryo-EM) structures of the ribosome complex with aa-tRNA and EF-Tu blocked by the antibiotic kirromycin provide insights into the mechanistic details of the long-range signalling responsible for GTPase activation.