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Misexpression screen in Drosophila melanogaster aiming to reveal novel factors involved in formation of body parts

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Jaeckle,  H.
Department of Molecular Developmental Biology, MPI for biophysical chemistry, Max Planck Society;

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Schaefer,  U.
Department of Molecular Developmental Biology, MPI for biophysical chemistry, Max Planck Society;

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Citation

Grieder, N. C., Charlafti, I., Kloter, U., Jaeckle, H., Schaefer, U., & Gehring, W. J. (2007). Misexpression screen in Drosophila melanogaster aiming to reveal novel factors involved in formation of body parts. Genetics, 175(4), 1707-1718. Retrieved from http://www.genetics.org/cgi/content/full/175/4/1707.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0012-E175-A
Abstract
To identify novel factors that lead a fly imaginal disc to adopt its developmental fate, we carried out a modular dominant misexpression screen in imaginal discs. We have identified two factors that appear to change the fate of the respective body structure and appear to lead to the transformation of a body part. In one mutant line, notum tissue, normally derived from wing imaginal tissue, formed close to the site of the sternopleural bristles, which are leg disc derivatives. In the other line, the arista is transformed into a tubular structure, resembling an abnormal leg. We found that ectopic expression of abrupt was responsible for this potential transformation of the arista.