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Adaptation of nanoarrays for the study of α-synuclein aggregation - preliminary results

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Hoyer,  W.
Department of Molecular Biology, MPI for biophysical chemistry, Max Planck Society;

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Jovin,  T. M.
Department of Molecular Biology, MPI for biophysical chemistry, Max Planck Society;

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Citation

Dietrich, H. R. C., van den Doel, R. L., Hoyer, W., van Oel, W., Lung, G. L., Garini, Y., et al. (2005). Adaptation of nanoarrays for the study of α-synuclein aggregation - preliminary results. In D. Nicolau (Ed.), Imaging, manipulation, and analysis of biomolecules and cells: fundamentals and applications III (pp. 395-402). Bellingham, Wash.: Society of Photo Optical Instrumentation Engineers.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0012-E9F4-6
Abstract
In previous publications we have shown that we can perform enzymatic reactions in nanoarrays by means of a microarray-reader based on a conventional microscope. In this publication we report on a modification of this system in order to monitor the aggregation kinetics of the natively unfolded protein α-synuclein. We describe the motivation for this development, the problems associated with the miniaturization of the aggregation assay, and the validation of our modifications.