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Synthesis of indole-containing diheteroarylethenes. New probes for photochromic FRET (pcFRET)

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Vermeij,  R. J.
Department of Molecular Biology, MPI for biophysical chemistry, Max Planck Society;

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Jares-Erijman,  E. A.
Department of Molecular Biology, MPI for biophysical chemistry, Max Planck Society;

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Citation

Giordano, L., Vermeij, R. J., & Jares-Erijman, E. A. (2005). Synthesis of indole-containing diheteroarylethenes. New probes for photochromic FRET (pcFRET). ARKIVOC, xii, 268-281. Retrieved from http://www.arkat-usa.org/get-file/19615/.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-EAC5-8
Abstract
This paper reports a synthesis of novel diheteroarylethenes functionalized for coupling to biomolecules starting from indole derivatives. The strategy is based on the derivatization at the N-atom in the indole substructure. TBDMS protection proved to be superior over BOC protection schemes, leading to higher yields in the overall synthesis. The suitability of the new derivatives as acceptors for pcFRET was calculated for selected donors.