Cerebral proton magnetic resonance spectroscopy of a patient with giant axonal 
neuropathy

Brockmann, K.; Pouwels, P. J. W.; Dechent, P.; Flanigan, K. M.; Frahm, J.; Hanefeld, F.

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Cerebral proton magnetic resonance spectroscopy of a patient with giant axonal neuropathy

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Dechent, P.
Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society;

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Frahm, J.
Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society;

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Brockmann, K., Pouwels, P. J. W., Dechent, P., Flanigan, K. M., Frahm, J., & Hanefeld, F. (2003). Cerebral proton magnetic resonance spectroscopy of a patient with giant axonal neuropathy. Brain & Development, 25(1), 45-50. Retrieved from http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T50-47C3Y0T-5-F&_cdi=4988&_user=38661&_pii=S0387760402001547&_orig=search&_coverDate=01%2F31%2F2003&_sk=999749998&view=c&wchp=dGLbVzb-zSkzV&md5=00e9cd78c8e58a7b83fdba0d55ccbfb7&ie=/sdarticle.pdf.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-F1AA-2

Abstract

Magnetic resonance imaging of a girl with giant axonal neuropathy revealed a progressive white matter disease. In close agreement with histopathological features reported previously, localized proton magnetic resonance spectroscopy at 9 and 12 years of age indicated a specific damage or loss of axons (reduced N-acetylaspartate and N-acetylaspartylglutamate) accompanied by acute demyelination (elevated choline-containing compounds, myo-inositol, and lactate) in white matter as well as a generalized proliferation of glial cells (elevated choline-containing compounds and myo-inositol) in both gray and white matter. (C) 2002 Elsevier Science B.V. All rights reserved.