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Journal Article

Expression of a linker histone-like gene in the primordial germ cells in zebrafish


Mueller,  K.
Research Group of Laser Chemical Processing, MPI for biophysical chemistry, Max Planck Society;


Raz,  E.
Research Group of Germ Cell Development, MPI for biophysical chemistry, Max Planck Society;

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Mueller, K., Thisse, C., Thisse, B., & Raz, E. (2002). Expression of a linker histone-like gene in the primordial germ cells in zebrafish. Mechanisms of Development, 117(1-2), 253-257. Retrieved from http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T9H-461XNYM-1-7&_cdi=5115&_user=38661&_pii=S0925477302001740&_origin=search&_coverDate=09%2F30%2F2002&_sk=998829998&view=c&wchp=dGLbVlW-zSkzV&md5=1c0d7e66a768bd358e7581f8db48eebe&ie=/sdarticle.pdf.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-F324-F
Similar to many other organisms, specification of primordial germ cells (PGCs) in zebraftsh occurs during early development and depends on inheritance of 'germ plasm' determinants. Following their specification, the PGCs exhibit characteristic transcriptional profile and cell behaviour. Here we describe the cloning, expression pattern and sub-cellular localization of the zebrafish H I type linker histone, HIM, which is specifically expressed in the PGCs in the second phase of their development. HIM transcripts are uniformly distributed during blastula stages, but become restricted to the PGCs during gastrulation and remain visible in PGCs as they migrate towards the region of the gonad. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.