Conversion of cerebral cortex into basal ganglia in Emx2-/- Pax6sey/sey 
double-mutant mice

Muzio, L.; DiBenedetto, B.; Stoykova, A.; Boncinelli, E.; Gruss, P.; Mallamaci, A.

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Conversion of cerebral cortex into basal ganglia in Emx2^-/- Pax6^sey/sey double-mutant mice

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Stoykova, A.
Research Group of Molecular Developmental Neurobiology, MPI for biophysical chemistry, Max Planck Society;

Gruss, P.
Max Planck Society;

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Citation

Muzio, L., DiBenedetto, B., Stoykova, A., Boncinelli, E., Gruss, P., & Mallamaci, A. (2002). Conversion of cerebral cortex into basal ganglia in Emx2^-/- Pax6^sey/sey double-mutant mice. Nature Neuroscience, 5(8), 737-745. Retrieved from http://www.nature.com/neuro/journal/v5/n8/pdf/nn892.pdf.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-F354-1

Abstract

The molecular mechanisms that activate morphogenesis of cerebral cortex are currently the subject of intensive experimental analysis. Transcription factor genes of the homeobox, basic helix-loop-helix (bHLH) and zinc-finger families have recently been shown to have essential roles in this process. However, the actual selector genes activating corticogenesis have not yet been identified. Here we show that high-level expression of at least one functional allele of either of the homeobox genes Emx2 or Pax6 in the dorsal telencephalon is necessary and sufficient to stably activate morphogenesis of cerebral cortex and to repress that of adjacent structures, such as striatum.