English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Drosophila tracheal system formation involves FGF-dependent cell extensions contacting bridge-cells

MPS-Authors
/persons/resource/persons16049

Wolf,  C.
Department of Molecular Developmental Biology, MPI for biophysical chemistry, Max Planck Society;

/persons/resource/persons15121

Gerlach,  N.
Research Group of Molecular Organogenesis, MPI for biophysical chemistry, Max Planck Society;

/persons/resource/persons15806

Schuh,  R.
Research Group of Molecular Organogenesis, MPI for biophysical chemistry, Max Planck Society;

External Resource
No external resources are shared
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Wolf, C., Gerlach, N., & Schuh, R. (2002). Drosophila tracheal system formation involves FGF-dependent cell extensions contacting bridge-cells. EMBO Reports, 3(6), 563-568. Retrieved from http://www.nature.com/embor/journal/v3/n6/pdf/embor143.pdf.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0012-F39C-1
Abstract
Development of the ectodermally derived Drosophila tracheal system is based on branch outgrowth and fusion that interconnect metamerically arranged tracheal subunits into a highly stereotyped three-dimensional tubular structure. Recent studies have revealed that this process involves a specialized cell type of mesodermal origin, termed bridge-cell. Single bridge-cells are located between adjacent tracheal subunits and serve as guiding posts for the outgrowing dorsal trunk branches. We show that bridge-cell-approaching tracheal cells form filopodia-like cell extensions, which attach to the bridge-cell surface and are essential for the tracheal subunit interconnection. The results of both dominant-negative and gain-of-function experiments suggest that the formation of cell extensions require Cdc42-mediated Drosophila fibroblast growth factor activity.