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Journal Article

Murine developmental control genes.

MPS-Authors
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Kessel,  M.
Department of Molecular Cell Biology, MPI for biophysical chemistry, Max Planck Society;

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Gruss,  P.
Department of Molecular Cell Biology, MPI for biophysical chemistry, Max Planck Society;

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Citation

Kessel, M., & Gruss, P. (1990). Murine developmental control genes. Science, 249(4967), 374-379. doi:10.1126/science.1974085.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-0D7E-D
Abstract
Various strategies have been used to isolate genes that participate in the regulation of mouse development. Gene families that have been identified on the basis of their homology to motifs within Drosophila control genes or human transcription factor genes, namely homeobox (Hox), paired-box (Pax), and POU genes, can be compared with respect to gene organization, structure, and expression patterns. The functions of these genes can be analyzed molecularly in vitro and in vivo with the use of available mouse mutants or transgenic mice. In addition, it has been possible to generate gain- or loss-of-function mutations by random or targeted introduction of transgenes. Models derived from these studies can reveal the successive steps of developmental control on a genetic level.