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Phase transition from a gel to a fluid phase of cubic symmetry in dimyristoylphosphatidylcholine/myristic acid (1:2, mol/mol) bilayers.

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Heimburg,  T.
Research Group of Biophysics and Thermodynamics of Membranes, MPI for biophysical chemistry, Max Planck Society;

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Ryba,  N.
Department of Spectroscopy and Photochemical Kinetics, MPI for biophysical chemistry, Max Planck Society;

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Wuerz,  U.
Abteilung Kinetik der Phasenbildung, MPI for biophysical chemistry, Max Planck Society;

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Marsh,  D.
Department of Spectroscopy and Photochemical Kinetics, MPI for biophysical chemistry, Max Planck Society;

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602974.pdf
(Publisher version), 430KB

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Citation

Heimburg, T., Ryba, N., Wuerz, U., & Marsh, D. (1990). Phase transition from a gel to a fluid phase of cubic symmetry in dimyristoylphosphatidylcholine/myristic acid (1:2, mol/mol) bilayers. Biochimica et Biophysica Acta, 1025(1), 77-81. doi:10.1016/0005-2736(90)90192-Q.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-0DB2-6
Abstract
Aqueous dispersions (pH 4.0) of a 2:1 (mol/mol) mixture of myristic acid with dimyristoylphosphatidylcholine undergo a sharp transition at 45–47°C from a lamellar gel phase to a fluid phase which is optically isotropic. This fluid phase gives rise to 31P-NMR spectra, and 2H-NMR spectra of the chain-deuterated components, which are also isotropic. X-ray diffraction studies of the fluid phase at 49°C, reveal reflections with spacings in the ratio √2: (√3): √4: √6: √8, accompanied by a strong diffuse scatter. These reflections index on a cubic lattice of primitive space group Pn3 or Pn3m, or possibly the body-centered group Im3m, with a lattice constant of 21.2 nm. The dimensions of the phase are consistent with a structure composed of two systems of tetrahedrally (octahedrally) oriented inverted lipid cylinders, found for other cubic lipid phases with Pn3m (Im3m) symmetry. At higher temperatures the cubic phase gradually converts, with increasing temperature, to a coexisting inverted hexagonal phase.