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Journal Article

Variations of cervical vertebrae after expression of a Hox-1.1 transgene in mice.

MPS-Authors
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Kessel,  M.
Department of Molecular Cell Biology, MPI for biophysical chemistry, Max Planck Society;

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Balling,  R.
Department of Molecular Cell Biology, MPI for biophysical chemistry, Max Planck Society;

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Gruss,  P.
Department of Molecular Cell Biology, MPI for biophysical chemistry, Max Planck Society;

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Citation

Kessel, M., Balling, R., & Gruss, P. (1990). Variations of cervical vertebrae after expression of a Hox-1.1 transgene in mice. Cell, 61(2), 301-308. doi:10.1016/0092-8674(90)90810-2.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-0DF8-C
Abstract
To understand the function of murine homeobox genes, a genetic analysis is mandatory. We generated gain-of-function mutants by introducing genomic sequences of the Hox-1.1 gene under the control of a chicken beta-actin promoter into mice. Our previous data had shown that these transgenic mice are nonviable after birth and are born with craniofacial abnormalities. In a subsequent detailed analysis of severely affected animals, malformations of the basioccipital bone, the atlas, and the axis were observed. Manifestation of an additional vertebra, a proatlas, occurred at the craniocervical transition. The dominant interference of the Hox-1.1 transgene with developmental programs seems to occur around day 9 of gestation, the time of neural crest migration and somite differentiation. We discuss the resulting phenotype with respect to a developmental control function of Hox-1.1.