Voltage sensitivity of NMDA-receptor mediated postsynaptic currents.

Konnerth, A.; Keller, B. U.; Ballanyi, K.; Yaari, Y.

doi:10.1007/BF00230117

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Voltage sensitivity of NMDA-receptor mediated postsynaptic currents.

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Konnerth, A.
Research Group of Cellular Neurophysiology, MPI for biophysical chemistry, Max Planck Society;

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Keller, B. U.
Research Group of Cellular Neurophysiology, MPI for biophysical chemistry, Max Planck Society;

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Konnerth, A., Keller, B. U., Ballanyi, K., & Yaari, Y. (1990). Voltage sensitivity of NMDA-receptor mediated postsynaptic currents. Experimental Brain Research, 81(1), 209-212. doi: 10.1007/BF00230117.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-0EA5-B

Abstract

Patch-clamp techniques were used to record pharmacologically-isolated N-methyl-D-aspartate-mediated excitatory postsynaptic currents (NMDA-EPSCs) from dentate granule cells in thin rat hippocampal slices. Membrane voltage modulated these EPSCs in two ways. Firstly, depolarization from resting potential enhanced EPSC amplitudes, as expected for a voltage-dependent block by Mg2+ of synaptically activated NMDA receptor channels. Secondly, depolarization markedly prolonged the time course of decay of NMDA-EPSCs in normal and low extracellular Mg2+. Both mechanisms were complementary in establishing a strong dependence between membrane potential and the amount of charge, namely Ca2+, transferred through synaptically activated NMDA receptor channels, that presumably underlies induction of long-term potentiation in the hippocampus.