English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Identification of tissue-specific microRNAs from mouse

MPS-Authors
/persons/resource/persons15408

Lagos-Quintana,  M.
Research Group of Combinatorical Biochemistry, MPI for biophysical chemistry, Max Planck Society;

/persons/resource/persons15692

Rauhut,  R.
Department of Cellular Biochemistry, MPI for biophysical chemistry, Max Planck Society;

/persons/resource/persons16062

Yalcin,  A.
Department of Cellular Biochemistry, MPI for biophysical chemistry, Max Planck Society;

/persons/resource/persons15521

Meyer,  J.
Research Group of Combinatorical Biochemistry, MPI for biophysical chemistry, Max Planck Society;

/persons/resource/persons15434

Lendeckel,  W.
Research Group of Combinatorical Biochemistry, MPI for biophysical chemistry, Max Planck Society;

/persons/resource/persons15941

Tuschl,  T.
Research Group of Combinatorical Biochemistry, MPI for biophysical chemistry, Max Planck Society;

Locator
There are no locators available
Fulltext (public)

17048.pdf
(Publisher version), 0B

Supplementary Material (public)
There is no public supplementary material available
Citation

Lagos-Quintana, M., Rauhut, R., Yalcin, A., Meyer, J., Lendeckel, W., & Tuschl, T. (2002). Identification of tissue-specific microRNAs from mouse. Current Biology, 12(9), 735-739. Retrieved from http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6VRT-45X0D1F-N-8&_cdi=6243&_user=38661&_pii=S0960982202008096&_origin=search&_coverDate=04%2F30%2F2002&_sk=999879990&view=c&wchp=dGLbVzW-zSkzS&md5=b97c58758586f91c8a12a4f8ef46f9e0&ie=/sdarticle.pdf.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-94EF-7
Abstract
MicroRNAs (miRNAs) are a new class of noncoding RNAs, which are encoded as short inverted repeats in the genomes of invertebrates and vertebrates [1, 2]. It is believed that miRNAs are modulators of target mRNA translation and stability, although most target mRNAs remain to be identified. Here we describe the identification of 34 novel miRNAs by tissue- specific cloning of approximately 21-nucleotide RNAs from mouse. Almost all identified miRNAs are conserved in the human genome and are also frequently found in nonmammalian vertebrate genomes, such as pufferfish. In heart, liver, or brain, it is found that a single, tissue-specifically expressed miRNA dominates the population of expressed miRNAs and suggests a role for these miRNAs in tissue specification or cell lineage decisions. Finally, a miRNA was identified that appears to be the fruitfly and mammalian ortholog of C. elegans lin-4 stRNA.