Assessment of local brain activation: A simultaneous PET and near-infrared 
spectroscopy study

Villringer, Kersten; Minoshima, S.; Hock, C.; Obrig, Hellmuth; Ziegler, S.; Dirnagl, U.; Schwaiger, M.; Villringer, Arno

doi:10.1007/978-1-4899-0056-2_16

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Assessment of local brain activation: A simultaneous PET and near-infrared spectroscopy study

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Villringer, K., Minoshima, S., Hock, C., Obrig, H., Ziegler, S., Dirnagl, U., et al. (1997). Assessment of local brain activation: A simultaneous PET and near-infrared spectroscopy study. Advances in Experimental Medicine and Biology, 413, 149-153. doi:10.1007/978-1-4899-0056-2_16.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-A4FF-4

Abstract

In five healthy human subjects, near-infrared spectroscopy (NIRS) and positron emission tomography (PET) examinations were performed simultaneously. Changes in [oxy-Hb], [deoxy-Hb] and [total-Hb] as measured by NIRS over the left forehead were compared to measurements of cerebral blood flow by PET during rest and during performance of a calculation task and a Stroop task.

When a penetration depth of near-infrared light of 0.9 cm into the brain cortex was assumed, a statistically significant correlation between changes in CBF and changes in [total-Hb] was found. These data confirm the validity of NIRS measurements in human adults.