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Determining changes in NIR absorption using a layered model of the human head

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Steinbrink, J., Wabnitz, H., Obrig, H., Villringer, A., & Rinneberg, H. (2001). Determining changes in NIR absorption using a layered model of the human head. Physics in Medicine and Biology, 46, 879-896. doi:10.1088/0031-9155/46/3/320.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-A93A-1
Abstract
A theoretical approach is presented to determine absorption changes in different compartments of a layered structure from distributions of times of flight of photons. In addition resulting changes in spatial profiles of time-integrated intensity and mean time of flight are calculated. The capability of a single-distance, time-domain method to determine absorption changes with depth resolution is tested on a layered phantom. We apply this method to in vivo measurements on the human head (motor stimulation, Valsalva manoeuvre) and introduce a small-sized time-domain experimental set-up suitable for bedside monitoring.