Disrupting the experience of control in the human brain: pre-supplementary 
motor area contributes to the sense of agency.

Moore, James W.; Ruge, Diane; Wenke, Dorit; Rothwell, John C.; Haggard, Patrick

doi:10.1098/rspb.2010.0404

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Disrupting the experience of control in the human brain: pre-supplementary motor area contributes to the sense of agency.

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Wenke, Dorit
Department Psychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Department of Experimental, Clinical and Health Psychology, Ghent University, Ghent, Belgium;

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894930/
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Citation

Moore, J. W., Ruge, D., Wenke, D., Rothwell, J. C., & Haggard, P. (2010). Disrupting the experience of control in the human brain: pre-supplementary motor area contributes to the sense of agency. Proceedings of the Royal Society of London Series B-Biological Sciences, 277(1693), 2503-2509. doi:10.1098/rspb.2010.0404.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-AC4C-3

Abstract

The feeling of controlling events through one's actions is fundamental to human experience, but its neural basis remains unclear. This 'sense of agency' (SoA) can be measured quantitatively as a temporal linkage between voluntary actions and their external effects. We investigated the brain areas underlying this aspect of action awareness by using theta-burst stimulation to locally and reversibly disrupt human brain function. Disruption of the pre-supplementary motor area (pre-SMA), a key structure for preparation and initiation of a voluntary action, was shown to reduce the temporal linkage between a voluntary key-press action and a subsequent electrocutaneous stimulus. In contrast, disruption of the sensorimotor cortex, which processes signals more directly related to action execution and sensory feedback, had no significant effect. Our results provide the first direct evidence of a pre-SMA contribution to SoA. © 2010 The Royal Society