User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse




Journal Article

Evidence that glypican is a receptor mediating ß-amyloid neurotoxicity in PC12 cells

There are no MPG-Authors available
External Ressource
No external resources are shared
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available

Schulz, J. G., Megow, D., Reszka, R., Villringer, A., Einhaeupl, K. M., & Dirnagl, U. (1998). Evidence that glypican is a receptor mediating ß-amyloid neurotoxicity in PC12 cells. European Journal of Neuroscience, 10(6), 2085-1093. doi:10.1046/j.1460-9568.1998.00220.x.

Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-B319-2
Docking of β‐amyloid fibrils to neuronal or glial cell membranes may be an early, necessary and intervenable step during the progression of Alzheimer's disease. Formation of neurofibrillary tangles and amyloid plaques as well as neurotoxicity and inflammation may be direct or indirect consequences. In an attempt to find a receptor that mediates those effects, we assessed rat pheochromocytoma PC12 cell 3‐[4,5‐dimethylthiazol‐2‐yl]‐2,5‐diphenyl tetrazolium bromide (MTT) reduction after addition of β‐amyloid to the culture medium. Presence of competitive substances in the medium, cell‐surface treatment and specific block of cellular synthesis pathways helped to identify the heparan sulphate moiety of a glycosylphosphatidylinositol‐anchored protein likely to represent glypican as a possible receptor mediating β‐amyloid neurotoxicity.