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Measurements of hyperpolarized gas properties in the lung. Part III: 3He T1

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Möller,  Harald E.
MPI of Cognitive Neuroscience (Leipzig, -2003), The Prior Institutes, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Citation

Möller, H. E., Hedlund, L. W., Chen, X. J., Carey, M. R., Chawla, M. S., Wheeler, C. T., et al. (2001). Measurements of hyperpolarized gas properties in the lung. Part III: 3He T1. Magnetic Resonance in Medicine, 45(3), 421-430. doi:10.1002/1522-2594(200103)45:3<421:AID-MRM1055>3.0.CO;2-K.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-C585-A
Abstract
Hyperpolarized 3He spin-lattice relaxation was investigated in the guinea pig lung using spectroscopy and imaging techniques with a repetitive RF pulse series. T1 was dominated by interactions with oxygen and was used to measure the alveolar O2 partial pressure. In animals ventilated with a mixture of 79% 3He and 21% O2, T1 dropped from 19.6 sec in vivo to 14.6 sec after cardiac arrest, reflecting the termination of the intrapulmonary gas exchange. The initial difference in oxygen concentration between inspired and alveolar air, and the temporal decay during apnea were related to functional parameters. Estimates of oxygen uptake were 29 ± 11 mL min−1 kg−1 under normoxic conditions, and 9.0 ± 2.0 mL min−1 kg−1 under hypoxic conditions. Cardiac output was estimated to be 400 ± 160 mL min−1 kg−1. The functional residual capacity derived from spirometric magnetic resonance experiments varied with body mass between 5.4 ± 0.3 mL and 10.7 ± 1.1 mL. Magn Reson Med 45:421–430, 2001.