Role of nitric oxide in the coupling of cerebral blood flow to neuronal 
activation in rats

Dirnagl, U.; Lindauer, U.; Villringer, Arno

doi:10.1016/0304-3940(93)90343-J

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Role of nitric oxide in the coupling of cerebral blood flow to neuronal activation in rats

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Dirnagl, U., Lindauer, U., & Villringer, A. (1993). Role of nitric oxide in the coupling of cerebral blood flow to neuronal activation in rats. Neuroscience Letters, 149(1), 43-46. doi:10.1016/0304-3940(93)90343-J.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-D6A1-0

Abstract

We tested the hypothesis that nitric oxide (NO) is a mediator in the coupling of cerebral blood flow to neuronal activation. The production of NO was blocked in anesthetized rats with the NO-synthase inhibitor (l-NA). In controls, vibrissae stimulation for 60 s led to a fast (≤ 2 s), 17% increase in regional cerebral blood flow (rCBF) in the contralateral somatosensory cortex. Systemical (10 mg/kg) as well as topical (10−3 M) application of l-NA reduced the response to stimulation by approximately 50%. Systemical application primarily attenuated the early component of the response, whereas topical application led to an attenuation throughout the whole 60-s stimulation interval. We conclude that NO is involved in rCBF coupling to neuronal activation.