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Cytotoxicity and Inflammatory Potential of Soot Particles of Low-Emission Diesel Engines

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Su,  Dang Sheng
Inorganic Chemistry, Fritz Haber Institute, Max Planck Society;

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Müller,  Jens-Oliver
Inorganic Chemistry, Fritz Haber Institute, Max Planck Society;

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Jentoft,  Rolf E.
Inorganic Chemistry, Fritz Haber Institute, Max Planck Society;

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Schlögl,  Robert
Inorganic Chemistry, Fritz Haber Institute, Max Planck Society;

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Citation

Su, D. S., Serafino, A., Müller, J.-O., Jentoft, R. E., Schlögl, R., & Fiorito, S. (2008). Cytotoxicity and Inflammatory Potential of Soot Particles of Low-Emission Diesel Engines. Environmental Science and Technology, 42(5), 1761-1765. doi:10.1021/es0716554.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-FD53-F
Abstract
We evaluated, in vitro, the inflammatory and cytotoxic potential of soot particles from current low-emission (Euro IV) diesel engines toward human peripheral blood monocytederived macrophage cells. The result is surprising. At the same mass concentration, soot particles produced under lowemission conditions exhibit amuchhigher toxic and inflammatory potential than particles from an old diesel engine operating under black smoke conditions. This effect is assigned to the defective surface structure of Euro IV diesel soot, rendering it highly active. Our findings indicate that the reduction of soot emission in terms of mass does not automatically lead to a reduction of the toxic effects toward humans when the structure and functionality of the soot is changed, and thereby the biological accessibility and inflammatory potential of soot is increased.