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Tip-enhanced Raman spectra of picomole quantities of DNA nucleobases at Au(111)

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Domke,  Katrin F.
Physical Chemistry, Fritz Haber Institute, Max Planck Society;

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Zhang,  Dai
Physical Chemistry, Fritz Haber Institute, Max Planck Society;

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Pettinger,  Bruno
Physical Chemistry, Fritz Haber Institute, Max Planck Society;

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Citation

Domke, K. F., Zhang, D., & Pettinger, B. (2007). Tip-enhanced Raman spectra of picomole quantities of DNA nucleobases at Au(111). Journal of the American Chemical Society, 129(21), 6708-6709. doi:10.1021/ja071107q.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0011-00F7-C
Abstract
We show that label-free detection of picomole amounts of the four nucleobases, respectively, adsorbed at atomically smooth Au(111) is straightforward with tip-enhanced Raman (TER) spectroscopy. In addition to TER spectra that allow identification of the corresponding DNA base, topographic images of the nanometer-sized sample can be obtained. Only 130 adenine molecules present in the enhanced field region in the tip-sample gap are sufficient to record the adenine fingerprint, that is, the Raman band of the characteristic ring-breathing mode at 734 cm-1.