Mid-infrared spectroscopy of protected peptides in the gas phase: a probe of 
the backbone conformation

Compagnon, Isabelle; Oomens, Jos; Meijer, Gerard; Helden, Gert von

doi:10.1021/ja055378h

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Mid-infrared spectroscopy of protected peptides in the gas phase: a probe of the backbone conformation

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Meijer, Gerard
Molecular Physics, Fritz Haber Institute, Max Planck Society;

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Helden, Gert von
Molecular Physics, Fritz Haber Institute, Max Planck Society;

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Citation

Compagnon, I., Oomens, J., Meijer, G., & Helden, G. v. (2006). Mid-infrared spectroscopy of protected peptides in the gas phase: a probe of the backbone conformation. Journal of the American Chemical Society, 128(11), 3592-3597. doi:10.1021/ja055378h.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0011-055C-2

Abstract

Infrared/UV hole-burning spectroscopy is performed on individual conformers of the protected dipeptide Z-Aib-Pro-NHMe. The extended IR range probed in this study allows one to elucidate both the H-bonding motif (5-7 μm) as well as the backbone structure (7-10 μm). Comparison with DFT calculations shows that the backbone is locally constrained to an α-conformation by Aib and to a γ-turn by Pro. The γ-turn motif observed here is intriguing since the condensed phase structure is known to be a β-turn. This is the first actual observation of such a discrepancy, and it emphasizes the subtle balance between intra- and intermolecular forces, which is responsible for the relative stability of the different secondary structure motifs.