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Book Chapter

Intracellular networks of interacting molecular machines


Mikhailov,  Alexander S.
Physical Chemistry, Fritz Haber Institute, Max Planck Society;

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Mikhailov, A. S. (2005). Intracellular networks of interacting molecular machines. In D. Armbruster, K. Kaneko, & A. S. Mikhailov (Eds.), Networks of Interacting Machines – Production Organization in Complex Industrial Systems and Biological Cells (pp. 177-202). Singapore: World Scientific.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0011-0A19-E
Biological cells can be viewed as networks formed by molecular machines. The coordination in operations of individual machines in such networks is not externally imposed, but develops internally as a result of interactions between the machines, through a self-organization process. As an example, we consider a population of allosteric enzymes with product activation and show that this network can undergo spontaneous transitions to different synchronous regimes corresponding to just-in-time production. Analyzing a toy model of cross-coupled neural networks, we find furthermore that similar synchronization transitions are possible when the dynamics of individual elements is highly complex.