Gene therapy for HIV infection: what does it need to make it work?

von Laer, Dorothee; Hasselmann, Susanne; Hasselmann, Klaus

doi:10.1002/jgm.908

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Gene therapy for HIV infection: what does it need to make it work?

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Hasselmann, Susanne
MPI for Meteorology, Max Planck Society;

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Hasselmann, Klaus
MPI for Meteorology, Max Planck Society;

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von Laer, D., Hasselmann, S., & Hasselmann, K. (2006). Gene therapy for HIV infection: what does it need to make it work? Journal of Gene Medicine, 8, 658-667. doi:10.1002/jgm.908.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0011-FC7F-A

Abstract

The efficacy of antiviral drug therapy for HIV infection is limited by toxicity and viral resistance. Thus, alternative therapies need to be explored. Several gene therapeutic strategies for HIV infection have been developed, but in clinical testing therapeutically effective levels of the transgene product were not achieved. This review focuses on the determinants of therapeutic efficacy and discusses the potential and also the limits of current gene therapy approaches for HIV infection. Copyright © 2006 John Wiley & Sons, Ltd.