Autoimmunity's next top models

Wekerle, Hartmut; Fluegel, Alexander; Fugger, Lars; Schett, Georg; Serreze, David

doi:10.1038/nm.2635

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Autoimmunity's next top models

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Wekerle, Hartmut
Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society;

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Citation

Wekerle, H., Fluegel, A., Fugger, L., Schett, G., & Serreze, D. (2012). Autoimmunity's next top models. Nature Medicine, 18(1), 66-70. doi:10.1038/nm.2635.

Cite as: https://hdl.handle.net/11858/00-001M-0000-000F-41B1-C

Abstract

Animal models are indispensable for studying disease pathogenesis and
discovering new treatments for human organ-specific autoimmune
diseases. However, there is a need of more refined paradigms for these
models. Ideally, a small-animal model should represent the clinical
features of human disease in their entirety. Disease in the animals
should develop spontaneously, should be followed over an extended
period of time and should involve the genetic, molecular and cellular
elements that contribute to human pathogenesis.