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Journal Article

Mitochondrial cristae revealed with focused light.

MPS-Authors
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Schmidt,  R.
Department of NanoBiophotonics, MPI for biophysical chemistry, Max Planck Society;

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Wurm,  C.
Department of NanoBiophotonics, MPI for biophysical chemistry, Max Planck Society;

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Punge,  A.
Department of NanoBiophotonics, MPI for biophysical chemistry, Max Planck Society;

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Egner,  A.
Department of NanoBiophotonics, MPI for biophysical chemistry, Max Planck Society;

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Jakobs,  S.
Research Group of Mitochondrial Structure and Dynamics, MPI for biophysical chemistry, Max Planck Society;

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Hell,  S. W.       
Department of NanoBiophotonics, MPI for biophysical chemistry, Max Planck Society;

External Resource

http://pubs.acs.org/doi/pdfplus/10.1021/nl901398t
(Publisher version)

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Fulltext (public)

1478142.pdf
(Publisher version), 141KB

Supplementary Material (public)

1478142-Suppl.pdf
(Supplementary material), 933KB

Citation

Schmidt, R., Wurm, C., Punge, A., Egner, A., Jakobs, S., & Hell, S. W. (2009). Mitochondrial cristae revealed with focused light. Nano Letters, 9(6), 2508-2510. doi:10.1021/nl901398t.


Cite as: https://hdl.handle.net/11858/00-001M-0000-000F-9CE6-1
Abstract
Because of the diffraction resolution barrier, optical microscopes have so far failed in visualizing the mitochondrial cristae, that is, the folds of the inner membrane of this 200 to 400 nm diameter sized tubular organelle. Realizing a ∼30 nm isotropic subdiffraction resolution in isoSTED fluorescence nanoscopy, we have visualized these essential structures in the mitochondria of intact cells. We find a pronounced heterogeneity in the cristae arrangements even within individual mitochondrial tubules.