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Poster

Development of multimodal imaging probes for neuroanatomical connectivity studies in vivo by means of MRI

MPG-Autoren
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Mamedov,  I
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Engelmann,  J
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Hagberg,  G
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Eschenko,  O
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

Externe Ressourcen

https://archive.ismrm.org/2012/1632.html
(Zusammenfassung)

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Zitation

Mamedov, I., Engelmann, J., Hagberg, G., Eschenko, O., & Logothetis, N. (2012). Development of multimodal imaging probes for neuroanatomical connectivity studies in vivo by means of MRI. Poster presented at 20th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-0013-B796-D
Zusammenfassung
A Gd3+ based paramagnetic dextran conjugate has been developed, which enables the tracking of neuroanatomical connectivity in the brain by both MR and optical imaging. Cell studies demonstrated that the synthesized tracer was efficiently internalized into neuronal cells and transported toward the axons. Furthermore, our preliminary in vivo experiments revealed efficient transportation of the conjugate, thereby proving its applicability for neuroanatomical studies by T1-weighted MRI. Initial in vivo experiments in rodents demonstrated the significant potential of this method.