Perfusion-based High-Resolution Functional Imaging in the Human Brain at 7 Tesla

Pfeuffer, J; Adriany, G; Shmuel, A; Yacoub, E; Van de Moortele, P-F; Hu, X; Ugurbil, K

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Perfusion-based High-Resolution Functional Imaging in the Human Brain at 7 Tesla

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Pfeuffer, J., Adriany, G., Shmuel, A., Yacoub, E., Van de Moortele, P.-F., Hu, X., et al. (2002). Perfusion-based High-Resolution Functional Imaging in the Human Brain at 7 Tesla. In 10th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2002).

Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-DFE0-5

Abstract

In this paper, CBF-based functional imaging is reported at sub-millimeter resolution (0.9 mm) in humans for the first time. High sensitivity was made possible by signal-to-noise gains at the high magnetic field of 7 Tesla and by using a novel RF combination coil design. In addition, 0.9-mm in-plane resolution with gradient-echo echo-planar imaging was achieved in a single-shot by reducing the field-of-view. Functional CBF data were compared with functional BOLD data to reveal that the CBF response was more localized and that, for CBF, large contrast-to-noise gains were obtained at high spatial resolution.