Spatial Dependence of the Nonlinear BOLD Response at Short Stimulus Duration

Pfeuffer, J; McCullough , JC; Van de Moortele , P-F; Ugurbil, K; Hu, X

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Spatial Dependence of the Nonlinear BOLD Response at Short Stimulus Duration

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Pfeuffer, J., McCullough, J., Van de Moortele, P.-F., Ugurbil, K., & Hu, X. (2002). Spatial Dependence of the Nonlinear BOLD Response at Short Stimulus Duration. In 10th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2002).

Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-DFE4-E

Abstract

Non-linearities in the measured BOLD data were found for the response integral and width. With the high sensitivity at 7T, a voxel-based analysis was feasible and was used to investigate the spatial dependence of the non-linearities at high spatial resolution. Correlation between response onset and non-linearity suggests that the origin of the observations are a tissue-specific phenomenon. Comparison with 4T and 1.5T data also indicates a field dependence. The observed non-linearity at short stimulus duration (SD) has likely a considerable hemodynamic contribution and thus must be accounted for in event-related fMRI paradigms.