date: 2013-07-30T09:13:06Z
pdf:PDFVersion: 1.4
pdf:docinfo:title: The Molecular Fingerprint of High Grade Serous Ovarian Cancer Reflects Its Fallopian Tube Origin
xmp:CreatorTool: PScript5.dll Version 5.2.2
access_permission:can_print_degraded: true
subject: High grade serous ovarian cancer (HGSC), the most lethal and frequent type of epithelial ovarian cancer (EOC), has poor long term prognosis due to a combination of factors: late detection, great metastatic potential and the capacity to develop resistance to available therapeutic drugs. Furthermore, there has been considerable controversy concerning the etiology of this malignancy. New studies, both clinical and molecular, strongly suggest that HGSC originates not from the surface of the ovary, but from the epithelial layer of the neighboring fallopian tube fimbriae. In this paper we summarize data supporting the central role of fallopian tube epithelium in the development of HGSC. Specifically, we address cellular pathways and regulatory mechanisms which are modulated in the process of transformation, but also genetic changes which accumulate during disease progression. Similarities between fallopian tube mucosa and the malignant tissue of HGSC warrant a closer analysis of homeostatic mechanisms in healthy epithelium in order to elucidate key steps in disease development. Finally, we highlight the importance of the cancer stem cell (CSC) identification and understanding of its niche regulation for improvement of therapeutic strategies.
dc:format: application/pdf; version=1.4
pdf:docinfo:creator_tool: PScript5.dll Version 5.2.2
access_permission:fill_in_form: true
pdf:encrypted: false
dc:title: The Molecular Fingerprint of High Grade Serous Ovarian Cancer Reflects Its Fallopian Tube Origin
modified: 2013-07-30T09:13:06Z
cp:subject: High grade serous ovarian cancer (HGSC), the most lethal and frequent type of epithelial ovarian cancer (EOC), has poor long term prognosis due to a combination of factors: late detection, great metastatic potential and the capacity to develop resistance to available therapeutic drugs. Furthermore, there has been considerable controversy concerning the etiology of this malignancy. New studies, both clinical and molecular, strongly suggest that HGSC originates not from the surface of the ovary, but from the epithelial layer of the neighboring fallopian tube fimbriae. In this paper we summarize data supporting the central role of fallopian tube epithelium in the development of HGSC. Specifically, we address cellular pathways and regulatory mechanisms which are modulated in the process of transformation, but also genetic changes which accumulate during disease progression. Similarities between fallopian tube mucosa and the malignant tissue of HGSC warrant a closer analysis of homeostatic mechanisms in healthy epithelium in order to elucidate key steps in disease development. Finally, we highlight the importance of the cancer stem cell (CSC) identification and understanding of its niche regulation for improvement of therapeutic strategies.
pdf:docinfo:subject: High grade serous ovarian cancer (HGSC), the most lethal and frequent type of epithelial ovarian cancer (EOC), has poor long term prognosis due to a combination of factors: late detection, great metastatic potential and the capacity to develop resistance to available therapeutic drugs. Furthermore, there has been considerable controversy concerning the etiology of this malignancy. New studies, both clinical and molecular, strongly suggest that HGSC originates not from the surface of the ovary, but from the epithelial layer of the neighboring fallopian tube fimbriae. In this paper we summarize data supporting the central role of fallopian tube epithelium in the development of HGSC. Specifically, we address cellular pathways and regulatory mechanisms which are modulated in the process of transformation, but also genetic changes which accumulate during disease progression. Similarities between fallopian tube mucosa and the malignant tissue of HGSC warrant a closer analysis of homeostatic mechanisms in healthy epithelium in order to elucidate key steps in disease development. Finally, we highlight the importance of the cancer stem cell (CSC) identification and understanding of its niche regulation for improvement of therapeutic strategies.
pdf:docinfo:creator: Mirjana Kessler, Christina Fotopoulou and Thomas Meyer
meta:author: Mirjana Kessler, Christina Fotopoulou and Thomas Meyer
meta:creation-date: 2013-03-25T07:14:58Z
created: 2013-03-25T07:14:58Z
access_permission:extract_for_accessibility: true
Creation-Date: 2013-03-25T07:14:58Z
Author: Mirjana Kessler, Christina Fotopoulou and Thomas Meyer
producer: Acrobat Distiller 10.1.4 (Windows)
pdf:docinfo:producer: Acrobat Distiller 10.1.4 (Windows)
pdf:unmappedUnicodeCharsPerPage: 0
dc:description: High grade serous ovarian cancer (HGSC), the most lethal and frequent type of epithelial ovarian cancer (EOC), has poor long term prognosis due to a combination of factors: late detection, great metastatic potential and the capacity to develop resistance to available therapeutic drugs. Furthermore, there has been considerable controversy concerning the etiology of this malignancy. New studies, both clinical and molecular, strongly suggest that HGSC originates not from the surface of the ovary, but from the epithelial layer of the neighboring fallopian tube fimbriae. In this paper we summarize data supporting the central role of fallopian tube epithelium in the development of HGSC. Specifically, we address cellular pathways and regulatory mechanisms which are modulated in the process of transformation, but also genetic changes which accumulate during disease progression. Similarities between fallopian tube mucosa and the malignant tissue of HGSC warrant a closer analysis of homeostatic mechanisms in healthy epithelium in order to elucidate key steps in disease development. Finally, we highlight the importance of the cancer stem cell (CSC) identification and understanding of its niche regulation for improvement of therapeutic strategies.
Keywords: serous ovarian cancer; fallopian tube; p53 signature; STIC; cellular transformation; cancer stem cells (CSC); tumor microenvironment 
access_permission:modify_annotations: true
dc:creator: Mirjana Kessler, Christina Fotopoulou and Thomas Meyer
description: High grade serous ovarian cancer (HGSC), the most lethal and frequent type of epithelial ovarian cancer (EOC), has poor long term prognosis due to a combination of factors: late detection, great metastatic potential and the capacity to develop resistance to available therapeutic drugs. Furthermore, there has been considerable controversy concerning the etiology of this malignancy. New studies, both clinical and molecular, strongly suggest that HGSC originates not from the surface of the ovary, but from the epithelial layer of the neighboring fallopian tube fimbriae. In this paper we summarize data supporting the central role of fallopian tube epithelium in the development of HGSC. Specifically, we address cellular pathways and regulatory mechanisms which are modulated in the process of transformation, but also genetic changes which accumulate during disease progression. Similarities between fallopian tube mucosa and the malignant tissue of HGSC warrant a closer analysis of homeostatic mechanisms in healthy epithelium in order to elucidate key steps in disease development. Finally, we highlight the importance of the cancer stem cell (CSC) identification and understanding of its niche regulation for improvement of therapeutic strategies.
dcterms:created: 2013-03-25T07:14:58Z
Last-Modified: 2013-07-30T09:13:06Z
dcterms:modified: 2013-07-30T09:13:06Z
title: The Molecular Fingerprint of High Grade Serous Ovarian Cancer Reflects Its Fallopian Tube Origin
xmpMM:DocumentID: uuid:a9be96b4-7be8-4633-b6c5-2eb8edf8064f
Last-Save-Date: 2013-07-30T09:13:06Z
pdf:docinfo:keywords: serous ovarian cancer; fallopian tube; p53 signature; STIC; cellular transformation; cancer stem cells (CSC); tumor microenvironment 
pdf:docinfo:modified: 2013-07-30T09:13:06Z
meta:save-date: 2013-07-30T09:13:06Z
Content-Type: application/pdf
X-Parsed-By: org.apache.tika.parser.DefaultParser
creator: Mirjana Kessler, Christina Fotopoulou and Thomas Meyer
dc:subject: serous ovarian cancer; fallopian tube; p53 signature; STIC; cellular transformation; cancer stem cells (CSC); tumor microenvironment 
access_permission:assemble_document: true
xmpTPg:NPages: 26
pdf:charsPerPage: 2316
access_permission:extract_content: true
access_permission:can_print: true
meta:keyword: serous ovarian cancer; fallopian tube; p53 signature; STIC; cellular transformation; cancer stem cells (CSC); tumor microenvironment 
access_permission:can_modify: true
pdf:docinfo:created: 2013-03-25T07:14:58Z