Amphipathic DNA Origami Nanoparticles to Scaffold and Deform Lipid Membrane 
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Czogalla, Aleksander; Kauert, Dominik J.; Franquelim, Henri G.; Uzunova, Veselina; Zhang, Yixin; Seidel, Ralf; Schwille, Petra

doi:10.1002/anie.201501173

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Amphipathic DNA Origami Nanoparticles to Scaffold and Deform Lipid Membrane Vesicles

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Franquelim, Henri G.
Schwille, Petra / Cellular and Molecular Biophysics, Max Planck Institute of Biochemistry, Max Planck Society;

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Schwille, Petra
Schwille, Petra / Cellular and Molecular Biophysics, Max Planck Institute of Biochemistry, Max Planck Society;

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引用

Czogalla, A., Kauert, D. J., Franquelim, H. G., Uzunova, V., Zhang, Y., Seidel, R., & Schwille, P. (2015). Amphipathic DNA Origami Nanoparticles to Scaffold and Deform Lipid Membrane Vesicles. Angewandte Chemie International Edition, 54(22), 6501-6505. doi:10.1002/anie.201501173.

引用: https://hdl.handle.net/11858/00-001M-0000-0027-A723-6

要旨

We report a synthetic biology-inspired approach for the engineering of amphipathic DNA origami structures as membrane-scaffolding tools. The structures have a flat membrane-binding interface decorated with cholesterol-derived anchors. Sticky oligonucleotide overhangs on their side facets enable lateral interactions leading to the formation of ordered arrays on the membrane. Such a tight and regular arrangement makes our DNA origami capable of deforming free-standing lipid membranes, mimicking the biological activity of coat-forming proteins, for example, from the I-/F-BAR family.