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Homogeneous gold-catalyzed glycosylations in continuous flow

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Matthies,  Stefan
Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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McQuade,  D. Tyler
Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons121849

Seeberger,  Peter H.
Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Citation

Matthies, S., McQuade, D. T., & Seeberger, P. H. (2015). Homogeneous gold-catalyzed glycosylations in continuous flow. Organic Letters, 17(15), 3670-3673. doi:10.1021/acs.orglett.5b01584.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0027-D1BD-6
Abstract
The use of versatile alkynyl-building blocks that are activated by gold(I)-catalysis is demonstrated to efficiently generate a variety of glycosides in continuous flow. The application of a continuous flow setting to gold(I)-catalyzed glycosylations enables very short reaction times and excellent control of the reaction conditions.