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A bistable mechanism for directional sensing

MPG-Autoren
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Beta,  Carsten
Laboratory for Fluid Dynamics, Pattern Formation and Biocomplexity, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

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Amselem,  Gabriel
Laboratory for Fluid Dynamics, Pattern Formation and Biocomplexity, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

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Bodenschatz,  Eberhard       
Laboratory for Fluid Dynamics, Pattern Formation and Biocomplexity, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

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Zitation

Beta, C., Amselem, G., & Bodenschatz, E. (2008). A bistable mechanism for directional sensing. New Journal of Physics, 10(8), 083015-1-083015-20. doi:10.1088/1367-2630/10/8/083015.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-0029-1363-4
Zusammenfassung
We present a generic mechanism for directional sensing in eukaryotic cells that is based on bistable dynamics. As the key feature of this modeling approach, the velocity of trigger waves in the bistable sensing system changes its sign across cells that are exposed to an external chemoattractant gradient. This is achieved by combining a two-component activator/inhibitor system with a bistable switch that induces an identical symmetry breaking for arbitrary gradient input signals. A simple kinetic example is designed to illustrate the dynamics of a bistable directional sensing mechanism in numerical simulations.