citation_keywords: endosome, FYVE, mRNA transport, PAM2, RRM, <italic>Ustilago maydis</italic>
citation_publication_date: 2015/05/18
og:image: https://cdn.elifesciences.org/images/elife_final_logo_rgb.jpg
citation_author_institution: Institute for Microbiology, Cluster of Excellence on Plant Sciences
citation_title: A FYVE zinc finger domain protein specifically links mRNA transport to endosome trafficking
og:site_name: eLife
citation_reference: citation_journal_title=Trends in Microbiology;citation_author=S. Al-Khodor;citation_author=CT. Price;citation_author=A. Kalia;citation_author=Y. Abu Kwaik;citation_title=Functional diversity of ankyrin repeats in microbial proteins;citation_pages=132-139;citation_volume=18;citation_year=2010;citation_doi=10.1016/j.tim.2009.11.004
citation_publisher: eLife Sciences Publications Limited
citation_id: 4/0/e06041
citation_journal_title: eLife
description: A FYVE zinc finger domain protein specifically links mRNA transport to endosome trafficking | An endosomal component employs a novel PAM2-like motif to recruit a key RNA-binding protein, which explains how mRNAs and associated ribosomes are attached to endosomes during coupled transport.
title: A FYVE zinc finger domain protein specifically links mRNA transport to endosome trafficking | eLife
citation_author_email: feldbrue@hhu.de
DC.Description: DNA contains the instructions to build proteins. These instructions are first copied to make a molecule of messenger RNA (or mRNA for short). A large machine called the ribosome then reads the mRNA molecule and translates it to build a protein. Many proteins must get to particular locations in a cell to carry out their roles. For some proteins, this is achieved by transporting the mRNAs to the right location before they get translated, via a process called ?mRNA trafficking?. However, mRNAs do not move by themselves; instead they bind to a host of mRNA-binding proteins, and the ribosomes that are required for translation to take place. Cells also move proteins between different locations using small bubble-like structures called vesicles. These vesicles are surrounded by a membrane, and so this process is known as ?membrane trafficking?. Previous work has shown that these two processes are often linked, as vesicles can also carry mRNA molecules. But it is not fully understood how mRNA molecules are connected to vesicles. Now, Pohlmann et al. have used a fungus called Ustilago maydis as a model system to investigate how mRNAs and vesicles can move together in cells that grow to form filament-like structures called hyphae. This fungus uses these filaments to penetrate into plant tissues and causes a disease called corn smut. The experiments revealed a vesicle protein called Upa1 that contains a new type of binding site that allows Upa1 to bring an important RNA-binding protein to the surface of vesicles. Since the RNA-binding protein binds mRNA and the translating ribosomes, this can explain how mRNAs can associate with membranes to move together along hyphae. When Pohlmann et al. engineered fungi that lacked the gene for Upa1, these mutants had problems transporting their mRNAs and associated ribosomes. These findings reveal a direct connection between mRNA trafficking and membrane trafficking. Future studies could now investigate whether similar processes take place in other cells that grow as long filaments, such as plant pollen tubes or nerve cells. These studies might provide new insights into plant reproduction or brain activity.
citation_issn: 2050-084X
citation_abstract_url: https://elifesciences.org/content/4/e06041v2/abstract
citation_public_url: https://elifesciences.org/content/4/e06041v2
citation_language: en
dc:title: A FYVE zinc finger domain protein specifically links mRNA transport to endosome trafficking | eLife
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DC.Publisher: eLife Sciences Publications Limited
citation_section: Cell Biology, Microbiology and Infectious Disease
citation_pdf_url: https://elifesciences.org/content/4/e06041.pdf
citation_xml_url: https://elife-publishing-cdn.s3.amazonaws.com/06041/elife-06041-v2.xml
DC.Contributor: Thomas Pohlmann
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citation_pmid: 25985087
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citation_journal_abbrev: eLife Sciences
DC.Rights: © 2015, Pohlmann et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
DC.Identifier: 10.7554/eLife.06041
og:title: A FYVE zinc finger domain protein specifically links mRNA transport to endosome trafficking
citation_author: Thomas Pohlmann
DC.Title: A FYVE zinc finger domain protein specifically links mRNA transport to endosome trafficking
citation_firstpage: e06041
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citation_funding_source: citation_funder=Deutsche Forschungsgemeinschaft (DFG);citation_grant_number=DFG FOR1334;citation_grant_recipient=Thomas Pohlmann
citation_doi: 10.7554/eLife.06041
DC.Language: en
DC.Date: 2015-05-18
citation_volume: 4
og:url: https://elifesciences.org/content/4/e06041
Content-Language: en