How Can We Improve the Existing Vaccine for Tuberculosis to Combat the Growing 
Number of Multi-Resistant Strains?

Kaufmann, Stefan H. E.

doi:10.21036/LTPUB10207

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How Can We Improve the Existing Vaccine for Tuberculosis to Combat the Growing Number of Multi-Resistant Strains?

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Kaufmann, Stefan H. E.
Department of Immunology, Max Planck Institute for Infection Biology, Max Planck Society;

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https://lt.org/publication/how-can-we-improve-existing-vaccine-tuberculosis-combat-growing-number-multi-resistant
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引用

Kaufmann, S. H. E. (2016). How Can We Improve the Existing Vaccine for Tuberculosis to Combat the Growing Number of Multi-Resistant Strains? doi:10.21036/LTPUB10207.

引用: https://hdl.handle.net/11858/00-001M-0000-002B-BB95-9

要旨

Each year 1.5 million people die of tuberculosis thus making it the number one killer of all contagious diseases. With the number of multi-resistant tuberculosis growing, currently available treatments are no longer as effective as they used to be. The existing vaccine does not protect against pulmonary tuberculosis which is the most common form of the disease and easily transmittable. In this video, STEFAN H. E. KAUFMANN describes how this existing vaccine was modified to trigger an additional component of the cellular immune response. The researchers showed that it achieved profound reduction of bacterial load in the lung and an excellent safety profile in preclinical studies. The vaccine candidate is currently undergoing clinical trials to be approved for humans.