A sustainable, semi-continuous flow synthesis of hydantoins

Vukelić, Stella; Koksch, Beate; Seeberger, Peter H.; Seeberger, Peter H.; Gilmore, Kerry

doi:10.1002/chem.201602609

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

タグ情報を表示リリース履歴を表示詳細要約

公開

学術論文

A sustainable, semi-continuous flow synthesis of hydantoins

MPS-Authors

/persons/resource/persons231706

Vukelić, Stella
Kerry Gilmore, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons121849

Seeberger, Peter H.
Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons127138

Gilmore, Kerry
Kerry Gilmore, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

External Resource

There are no locators available

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

フルテキスト (公開)

公開されているフルテキストはありません

付随資料 (公開)

There is no public supplementary material available

引用

Vukelić, S., Koksch, B., Seeberger, P. H., Seeberger, P. H., & Gilmore, K. (2016). A sustainable, semi-continuous flow synthesis of hydantoins. Chemistry – A European Journal, 22(38), 13451-13454. doi:10.1002/chem.201602609.

引用: https://hdl.handle.net/11858/00-001M-0000-002A-F4ED-E

要旨

Hydantoins are an important class of heterocycles with applications in pharmacy, agriculture, and as intermediates in organic synthesis. Traditional synthetic procedures to access hydantoins are target oriented with multiple synthetic steps, often use reagents that are not commercially available, and are not sustainable. Herein, an efficient process is described accessing hydantoins starting from commercially available amines using consecutive gas/liquid transformations (oxygen, carbon dioxide). This semi-continuous process produced ten benzylic/aliphatic hydantoins in good overall yields (52-84%).